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Frontispiece: Intramolecular Parallel [4+3] Cycloadditions of Cyclopropane 1,1‐Diesters with [3]Dendralenes: Efficient Construction of [5.3.0]Decane and Corresponding Polycyclic Skeletons
Author(s) -
Zhang Chi,
Tian Jun,
Ren Jun,
Wang Zhongwen
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780662
Subject(s) - cyclopropane , intramolecular force , cycloaddition , decane , natural product , chemistry , stereochemistry , organic synthesis , computational chemistry , organic chemistry , catalysis , ring (chemistry)
Cycloadditions Developing efficient and general strategies for construction of skeletally complex and diverse polycyclic skeletons in natural products is important and challenging in organic synthesis. In their Communication on page 1231 ff., Z. Wang and co‐workers demonstrate a [4+3]IMPC (intramolecular parallel cycloaddition) of cyclopropane 1,1‐diesters with [3]dendralenes. With a combination of the [4+3]IMPC and subsequent [4+ n ] cycloadditions, bridged trans ‐[5.3.0]decane skeleton and its corresponding structurally complex and diverse polycyclic ones are constructed efficiently. This strategy is believed to be of potential importance to natural product synthesis and drug discovery.