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Frontispiece: Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation
Author(s) -
Clarke Sarah L.,
McGlacken Gerard P.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780661
Subject(s) - trifluoromethylation , reagent , lipophilicity , fluorine , chemistry , organic chemistry , combinatorial chemistry , trifluoromethyl , alkyl
Fluorine Chemistry The introduction of fluorine groups to pharmaceutical compounds can have a dramatic effect on the lipophilicity and metabolic stability of the molecule in vivo. The use of methyl fluorosulfonyldifluoroacetate (MFSDA) as a relatively inexpensive reagent for trifluoromethylation was first reported in 1989. In their Minireview on page 1219 ff., S. L. Clarke and G. P. McGlacken take a look at the use of MFSDA in trifluoromethylation reactions.