Premium
Frontispiece: Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation
Author(s) -
Clarke Sarah L.,
McGlacken Gerard P.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780661
Subject(s) - trifluoromethylation , reagent , lipophilicity , fluorine , chemistry , organic chemistry , combinatorial chemistry , trifluoromethyl , alkyl
Fluorine Chemistry The introduction of fluorine groups to pharmaceutical compounds can have a dramatic effect on the lipophilicity and metabolic stability of the molecule in vivo. The use of methyl fluorosulfonyldifluoroacetate (MFSDA) as a relatively inexpensive reagent for trifluoromethylation was first reported in 1989. In their Minireview on page 1219 ff., S. L. Clarke and G. P. McGlacken take a look at the use of MFSDA in trifluoromethylation reactions.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom