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Frontispiece: Time‐Gated Detection of Cystathionine γ‐Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor
Author(s) -
Yao Yao,
Kong Chen,
Yin Liang,
Jain Atul D.,
Ratia Kiira,
Thatcher Gregory R. J.,
Moore Terry W.,
Driver Tom G.,
Miller Lawrence W.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780462
Subject(s) - luminescence , cystathionine gamma lyase , cystathionine beta synthase , chromophore , moiety , intramolecular force , hydrogen sulfide , chemistry , lanthanide , sulfide , azide , aryl , enzyme , photochemistry , stereochemistry , sulfur , biochemistry , cysteine , materials science , organic chemistry , optoelectronics , ion , alkyl
Lanthanide Probes Hydrogen sulfide (H 2 S) functions as a signaling second messenger, and inhibition of H 2 S‐producing enzymes may be a promising therapeutic strategy. The emissive lanthanide probe LLPS‐Ln III generates strong turn‐on luminescence via a unique mechanism. H 2 S‐mediated reduction of an aryl azide moiety triggers an intramolecular cyclization to form a chromophore that sensitizes Tb III or Eu III luminescence. Time‐gated detection with LLPS‐Ln III enabled high‐throughput screening for inhibition of H 2 S‐producing cystathionine γ‐lyase. For more details, see the Communication by L. W. Miller et al. on page 752 ff.