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Frontispiece: The Cysteine S‐Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences
Author(s) -
Calce Enrica,
De Luca Stefania
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201780261
Subject(s) - peptidomimetic , cysteine , covalent bond , alkylation , combinatorial chemistry , peptide , amino acid , chemistry , solid phase synthesis , posttranslational modification , molecule , bioavailability , cyclic peptide , biochemistry , stereochemistry , organic chemistry , biology , bioinformatics , catalysis , enzyme
Solid‐ and Solution‐Phase Synthesis Modification of amino acid side chains in order to introduce chemical and functional diversities is a powerful tool for preparing peptidomimetics. This approach allows effective improvement of the bioavailability and resistance to metabolic breakdown of peptide molecules with therapeutic potential. For more information, see the Minireview by S. De Luca and E. Calce on page 224 ff.