Catalytic Enantioselective Synthesis of Highly Functionalized Pentafluorosulfanylated Pyrrolidines

The first catalytic asymmetric synthesis of highly functionalized pentafluorosulfanylated pyrrolidines is described. The method, based on a 1,3‐dipolar cycloaddition reaction of aryl and heteroaryl‐substituted glycine Schiff bases with pentafluorosulfanyl acrylic esters, gave access to a broad range of pyrrolidines bearing aryl, naphtyl, and heteroaryl groups. By using Xing‐Phos as a catalyst, the corresponding products were obtained in good yields, good to high regioselectivity, and excellent diastereo‐ and enantioselectivities (up to 98 %  ee ). This methodology allowed the preparation of enantioenriched SF 5 compounds for the first time using an enantioselective approach.