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Reversible Nanogate System for Mesoporous Silica Nanoparticles Based on Diels–Alder Adducts
Author(s) -
Castillo Rafael R.,
HernándezEscobar David,
GómezGraña Sergio,
ValletRegí María
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706100
Subject(s) - nanocarriers , mesoporous silica , nanoparticle , materials science , surface modification , nanotechnology , drug delivery , mesoporous material , cycloaddition , colloidal gold , chemical engineering , organic chemistry , chemistry , catalysis , engineering
The implementation of nanoparticles as nanomedicines requires sophisticated surface modifications to reduce the immune response and enhance recognition abilities. Mesoporous silica nanoparticles present extraordinary host–guest abilities and facile surface functionalization. These two factors make them ideal candidates for the development of novel drug‐delivery systems, at the expense of increasing structural complexity. With this idea in mind, a system composed of triggerable and tunable silica nanoparticles was developed for application as drug‐delivery nanocarriers. Diels–Alder cycloaddition adducts were chosen as thermal‐responsive units that permitted the binding of gold nanocaps able to block the pores and allow the incorporation of targeting fragments. The capping efficiency was tested under different thermal conditions to give outstanding efficiencies within the physiological range and mild temperatures, as well as enhanced release under pulsing heating cycles, which showed the best release profiles.