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Magnetic Reduced Graphene Oxide/Nickel/Platinum Nanoparticles Micromotors for Mycotoxin Analysis
Author(s) -
MolineroFernández Águeda,
Jodra Adrián,
MorenoGuzmán María,
López Miguel Ángel,
Escarpa Alberto
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706095
Subject(s) - graphene , nanotechnology , materials science , magnetic nanoparticles , mycotoxin , platinum nanoparticles , nickel , biosensor , oxide , aptamer , detection limit , magnetic separation , platinum , nanoparticle , chemistry , catalysis , chromatography , metallurgy , biochemistry , food science , biology , genetics
Abstract Magnetic reduced graphene oxide/nickel/platinum nanoparticles (rGO/Ni/PtNPs) micromotors for mycotoxin analysis in food samples were developed for food‐safety diagnosis. While the utilization of self‐propelled micromotors in bioassays has led to a fundamentally new approach, mainly due to the greatly enhanced target–receptor contacts owing to their continuous movement around the sample and the associated mixing effect, herein the magnetic properties of rGO/Ni/PtNPs micromotors for mycotoxin analysis are additionally explored. The micromotor‐based strategy for targeted mycotoxin biosensing focused on the accurate control of micromotor‐based operations: 1) on‐the‐move capture of free aptamers by exploiting the adsorption (outer rGO layer) and catalytic (inner PtNPs layer) properties and 2) micromotor stopped flow in just 2 min by exploiting the magnetic properties (intermediate Ni layer). This strategy allowed fumonisin B1 determination with high sensitivity (limit of detection: 0.70 ng mL −1 ) and excellent accuracy (error: 0.05 % in certified reference material and quantitative recoveries of 104±4 % in beer) even in the presence of concurrent ochratoxin A (105–108±8 % in wines). These results confirm the developed approach as an innovative and reliable analytical tool for food‐safety monitoring, and confirm the role of micromotors as a new paradigm in analytical chemistry.