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A Synthetic Approach for the Rapid Preparation of BODIPY Conjugates and their use in Imaging of Cellular Drug Uptake and Distribution
Author(s) -
Krajcovicova Sona,
Stankova Jarmila,
Dzubak Petr,
Hajduch Marian,
Soural Miroslav,
Urban Milan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706093
Subject(s) - bodipy , conjugate , chemistry , distribution (mathematics) , fluorescence microscope , combinatorial chemistry , solid phase synthesis , fluorescence , cancer cell , nanotechnology , biophysics , biochemistry , cancer , materials science , biology , peptide , mathematical analysis , physics , mathematics , quantum mechanics , genetics
A solid‐phase synthetic (SPS) method was developed for the preparation of BODIPY‐labeled bioactive compounds that allows for fast and simple synthesis of conjugates for use in fluorescent microscopy. The approach was used to visualize cellular uptake and distribution of cytotoxic triterpenes in cancer cells.