Premium
Deracemization of a Racemic Compound by Using Tailor‐Made Additives
Author(s) -
Engwerda Anthonius H. J.,
van Schayik Pim,
Jagtenberg Henjo,
Meekes Hugo,
Rutjes Floris P. J. T.,
Vlieg Elias
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706088
Subject(s) - racemization , slurry , grinding , phase (matter) , materials science , organic chemistry , molecule , chemical engineering , combinatorial chemistry , chemistry , metallurgy , engineering , composite material
Abstract Viedma ripening is a process that combines abrasive grinding of a slurry of crystals with solution‐phase racemization, resulting in solid‐phase deracemization. One of the major disadvantages of Viedma ripening is that the desired compound needs to crystallize as a racemic conglomerate, accounting for only 5–10 % of all chiral molecules. Herein, we show that use of a chiral additive causes deracemization under conditions, in which the compound normally crystallizes as a racemic compound. Although this concerns a single example, it is envisioned that through this new approach the scope of Viedma ripening can be significantly expanded.