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Ruthenium‐Catalyzed Selective C−C Coupling of Allylic Alcohols with Free Indoles: Influence of the Metal Catalyst
Author(s) -
Xia YingQi,
Li Chao,
Liu Man,
Dong Lin
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706080
Subject(s) - catalysis , ruthenium , allylic rearrangement , chemistry , ketone , surface modification , metal , medicinal chemistry , alkylation , coupling reaction , organic chemistry , cascade , combinatorial chemistry , chromatography
Versatile reactive activities of allyl alcohols with free indoles in C−H functionalization reactions were investigated. Direct alkylation or cascade cyclization reactions could be selectively controlled based on the catalyst system: Ru(PPh 3 ) 3 Cl 2 provided C3‐substituted β‐ketone indoles whereas [Ru( p ‐cymene)Cl 2 ] 2 yielded cyclized indoles.