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Fluorescent Polyvinylphosphonate Bioconjugates for Selective Cellular Delivery
Author(s) -
Schwarzenböck Christina,
Schaffer Andreas,
Nößner Elfriede,
Nelson Peter J.,
Huss Ralf,
Rieger Bernhard
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706034
Subject(s) - biomolecule , conjugate , polymer , ethylene glycol , chemistry , bioconjugation , combinatorial chemistry , fluorescence , peg ratio , nanotechnology , biophysics , materials science , organic chemistry , biology , mathematical analysis , physics , mathematics , finance , quantum mechanics , economics
To date, many poly(ethylene glycol) (PEG) and poly( N ‐isopropylacrylamide) (PNIPAAm) biomolecule conjugates have been described, but they often show long response times, are not bio‐inert, or lose function in biological fluids. Herein, we present a modular synthetic approach to generate polyvinylphosphonate biomolecule conjugates. These conjugates exhibit a sharp phase transition temperature even under physiological conditions where few other examples with this property have been described to date. Furthermore, it was feasible to add biological functions to the polymers via the conjugation step. The polyvinylphosphonate cholesterol constructs are attached to the cellular membrane and the folic acid anchored polymers are shuttled into the cells. This is an exceptional finding through a straightforward synthetic approach.