Premium
Advanced Continuous Flow Platform for On‐Demand Pharmaceutical Manufacturing
Author(s) -
Zhang Ping,
Weeranoppanant Nopphon,
Thomas Dale A.,
Tahara Kohei,
Stelzer Torsten,
Russell Mary Grace,
O'Mahony Marcus,
Myerson Allan S.,
Lin Hongkun,
Kelly Liam P.,
Jensen Klavs F.,
Jamison Timothy F.,
Dai Chunhui,
Cui Yuqing,
Briggs Naomi,
Beingessner Rachel L.,
Adamo Andrea
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201706004
Subject(s) - continuous flow , process engineering , continuous production , ciprofloxacin hydrochloride , pharmaceutical manufacturing , manufacturing engineering , production (economics) , computer science , chemistry , biochemical engineering , engineering , chemical engineering , pharmacology , ciprofloxacin , medicine , biochemistry , economics , macroeconomics , antibiotics
As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time‐scale, we previously reported a refrigerator‐sized continuous flow system for the on‐demand production of essential medicines. Building on this technology, herein we report a second‐generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand‐alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.