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Co III ‐Catalyzed Isonitrile Insertion/Acyl Group Migration Between C−H and N−H bonds of Arylamides
Author(s) -
Kalsi Deepti,
Barsu Nagaraju,
Sundararaju Basker
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705710
Subject(s) - chemistry , intramolecular force , catalysis , medicinal chemistry , chelation , cobalt , stereochemistry , alcohol , migratory insertion , organic chemistry
A general efficient and site‐selective cobalt‐catalyzed insertion of isonitrile into C−H and N−H bonds of arylamides through C−H bond activation and alcohol assisted intramolecular trans ‐amidation is demonstrated. This straightforward approach overcomes the limitation by the presence of strongly chelating groups. Isolation of Co III ‐isonitrile complex B has been achieved for the first time to understand the reaction mechanism.