Premium
Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery
Author(s) -
Bychek Roman M.,
Levterov Vadym V.,
Sadkova Iryna V.,
Tolmachev Andrey A.,
Mykhailiuk Pavel K.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705708
Subject(s) - sulfonyl , drug discovery , chemistry , combinatorial chemistry , drug , organic chemistry , medicine , biochemistry , pharmacology , alkyl
Difluorocyclopropane‐containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF 3 /NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.