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Switching Multivalent DNA Complexation using Metal‐Controlled Cationic Supramolecular Self‐Assemblies
Author(s) -
Drożdż Wojciech,
Bessin Yannick,
Gervais Virginie,
Cao XiaoYu,
Lehn JeanMarie,
Stefankiewicz Artur R.,
Ulrich Sébastien
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705630
Subject(s) - supramolecular chemistry , cationic polymerization , dna , chemistry , metal , ligand (biochemistry) , coordination complex , combinatorial chemistry , self assembly , nanotechnology , polymer chemistry , materials science , molecule , organic chemistry , receptor , biochemistry
We provide a proof‐of‐principle that coordination chemistry drives the in situ self‐assembly of an inactive ligand into a multivalent cluster capable of effectively complexing DNA. We show that metal coordination and scavenging can be used to switch the multivalency of the system. Thus, controlled DNA complexation and decomplexation could be achieved.