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Formation of Water Channels in the Crystalline Hydrates of Macrocyclic Compounds
Author(s) -
Patil Rahul S.,
Zhang Chen,
Sikligar Kanishka,
Baker Gary A.,
Atwood Jerry L.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705609
Subject(s) - surface modification , solubility , intermolecular force , chemistry , conformational isomerism , clathrate hydrate , organic chemistry , combinatorial chemistry , hydrate , molecule
Abstract Crystalline hydrates of macrocyclic compounds such as pyroagllol[4]arenes (PgCs) and resorcin[4]arenes (RsCs) are rare owing to their lower water solubility. Functionalization of these macrocyclic compounds is an affordable way to enhance water solubility. However, functionalization also encounters the formation of multiple conformers and subsequent difficulty in purification of the product. Herein, four novel crystalline hydrates of functionalized PgCs and RsCs were synthesized. Formation of water channels and the effects of intermolecular interactions on the physical properties of these novel hydrates are discussed.