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Efficient Buchwald–Hartwig–Migita Cross‐Coupling for DNA Thioglycoconjugation
Author(s) -
Probst Nicolas,
Lartia Rémy,
Théry Océane,
Alami Mouâd,
Defrancq Eric,
Messaoudi Samir
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705371
Subject(s) - nucleobase , oligonucleotide , combinatorial chemistry , dna , chemistry , coupling (piping) , oligonucleotide synthesis , materials science , biochemistry , metallurgy
An efficient method for the thioglycoconjugation of iodinated oligonucleotides by Buchwald–Hartwig–Migita cross‐coupling under mild conditions is reported. The method enables divergent synthesis of many different functionalized thioglycosylated ODNs in good yields, without affecting the integrity of the other A, C, and G nucleobases.