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C−F Bond Activation by Silylium Cation/Phosphine Frustrated Lewis Pairs: Mono‐Hydrodefluorination of PhCF 3 , PhCF 2 H and Ph 2 CF 2
Author(s) -
Mallov Ian,
Ruddy Adam J.,
Zhu Hui,
Grimme Stefan,
Stephan Douglas W.
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705276
Subject(s) - phosphine , chemistry , aryl , frustrated lewis pair , lewis acids and bases , polymer chemistry , base (topology) , phosphine oxide , intermolecular force , medicinal chemistry , organic chemistry , alkyl , molecule , catalysis , mathematical analysis , mathematics
Single defluorination of aryl polyfluoromethyl functionalities is achieved by both intra‐ and intermolecular silylium cation/phosphine Lewis pairs. Phosphine‐captured aryl fluoromethyl cations are then treated with Brønsted base to complete the first mono‐hydrodefluorinations of PhCF 3 , Ph 2 CF 2 , and PhCF 2 .