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Front Cover: Binding of Hydrophobic Guests in a Coordination Cage Cavity is Driven by Liberation of “High‐Energy” Water (Chem. Eur. J. 7/2018)
Author(s) -
Metherell Alexander J.,
Cullen William,
Williams Nicholas H.,
Ward Michael D.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705259
Subject(s) - hydrogen bond , enthalpy , hydrophobic effect , molecule , binding energy , solvent , chemistry , economic shortage , interaction energy , contact angle , cage , hydrogen , crystallography , chemical physics , materials science , organic chemistry , thermodynamics , atomic physics , linguistics , physics , philosophy , mathematics , combinatorics , government (linguistics) , composite material
The cavity of a cubic coordination cage in water contains an ordered array of water molecules in a ‘high‐energy’ arrangement, because of the shortage of hydrogen‐bonding interactions arising from contact with the hydrophobic cage surface. Binding of hydrophobic guests releases these water molecules into the bulk solution, where they can optimise their hydrogen‐bonding interactions with the solvent; the resulting enthalpy gain is a major contributor to guest binding. More information can be found in the Full Paper by M. D. Ward et al. on page 1554.