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Exploring the Reactivity of Trifluoromethyl Tolueneselenosulfonate with Alkynes under Copper Catalysis
Author(s) -
Ghiazza Clément,
Debrauwer Vincent,
Billard Thierry,
Tlili Anis
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705231
Subject(s) - reagent , trifluoromethyl , electrophile , reactivity (psychology) , catalysis , ligand (biochemistry) , copper , chemistry , combinatorial chemistry , organic chemistry , medicine , biochemistry , alkyl , alternative medicine , receptor , pathology
The direct fluoroalkylselenolation of terminal alkynes is reported herein involving shelf stable electrophilic reagents TsSeR F . The use of these reagents allows for the first time performing the reaction under catalytic conditions (copper/ligand). Moreover, the presence of oxygen directing groups allows the selective addition of the reagents to alkynes, therefore yielding a new family of vinyl sulfones.