A General Asymmetric Formal Synthesis of Aza‐Baylis–Hillman Type Products under Bifunctional Catalysis | Zendy

Frías María | Zendy; Carrasco Ana Cristina | Zendy; Fraile Alberto | Zendy; Alemán José | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

A General Asymmetric Formal Synthesis of Aza‐Baylis–Hillman Type Products under Bifunctional Catalysis

Author(s) -

Frías María,

Carrasco Ana Cristina,

Fraile Alberto,

Alemán José

Publication year - 2018

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201705218

Subject(s) - bifunctional , chemistry , catalysis , enantioselective synthesis , lewis acids and bases , selectivity , combinatorial chemistry , organocatalysis , base (topology) , organic chemistry , formal synthesis , mathematics , mathematical analysis

Abstract A new organocatalytic strategy for the synthesis of enantioenriched aza‐Baylis–Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z / E selectivity and excellent enantioselectivities. Moreover, easy derivatizations of the final products led to important building blocks of organic synthesis such as 1,3‐aminoalcohols and Lewis base catalysts.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research