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A General Asymmetric Formal Synthesis of Aza‐Baylis–Hillman Type Products under Bifunctional Catalysis
Author(s) -
Frías María,
Carrasco Ana Cristina,
Fraile Alberto,
Alemán José
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705218
Subject(s) - bifunctional , chemistry , catalysis , enantioselective synthesis , lewis acids and bases , selectivity , combinatorial chemistry , organocatalysis , base (topology) , organic chemistry , formal synthesis , mathematics , mathematical analysis
A new organocatalytic strategy for the synthesis of enantioenriched aza‐Baylis–Hillman type products via a frustrated vinylogous reaction is presented. This process proceeds under mild conditions with good yields, completed Z / E selectivity and excellent enantioselectivities. Moreover, easy derivatizations of the final products led to important building blocks of organic synthesis such as 1,3‐aminoalcohols and Lewis base catalysts.