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Photoactivation of Ligands for Extrinsically and Intrinsically Triggered Disassembly of Amphiphilic Nanoassemblies
Author(s) -
Gao Jingjing,
Liu Xiaochi,
Secinti Hatice,
Jiang Ziwen,
Munkhbat Oyuntuya,
Xu Yisheng,
Guo Xuhong,
Thayumanavan S.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705217
Subject(s) - amphiphile , nanotechnology , drug delivery , biomedicine , computer science , chemistry , materials science , copolymer , biology , polymer , bioinformatics , organic chemistry
Specific response to the concurrent presence of two different inputs is one of the hallmarks of incorporating specificities in nature. Artificial nanoassemblies that concurrently respond to two very different inputs are of great interest in a variety of applications, especially in biomedicine. Here, we present a design strategy for amphiphilic nanoassemblies with such capabilities, enabled by photocaging a ligand moiety that is capable of binding to a specific protein. New molecular designs that offer nanoassemblies that respond to either of two inputs or only to the concurrent presence of two inputs are outlined. Such biomimetic nanoassemblies could find use in many applications, including drug delivery and diagnostics.