Premium
Metal‐Catalyzed Synthesis and Use of Thioesters: Recent Developments
Author(s) -
Hirschbeck Vera,
Gehrtz Paul H.,
Fleischer Ivana
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201705025
Subject(s) - decarbonylation , chemistry , thioester , reactivity (psychology) , aldol reaction , catalysis , combinatorial chemistry , dual role , organic synthesis , organic chemistry , enzyme , medicine , alternative medicine , pathology
While thioesters are common intermediates in biochemical processes, they are much less appreciated in organic synthesis, also compared to other carboxylic acid derivatives. However, their chemistry and reactivity is intriguing and diversified, reaching much further than the acyl substitution and aldol chemistry. Herein, we focus on metal‐catalyzed reactions for the synthesis of thioesters as well as their transformations. Reactions such as thiocarbonylation, cross‐coupling, decarbonylation, allylic substitution or dual photoredox/metal catalysis are discussed. On one hand, new atom economic methods allow for convenient synthesis of thioesters from well available starting materials. On the other hand, various synthetically important compounds can by synthesized due to the multifaceted reactivity of thioesters that we aimed to depict.