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Front Cover: Intra‐ versus Intermolecular Hydrogen Bonding: Solvent‐Dependent Conformational Preferences of a Common Supramolecular Binding Motif from 1 H NMR and Vibrational Circular Dichroism Spectra (Chem. Eur. J. 71/2017)
Author(s) -
Demarque Daniel P.,
Merten Christian
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704986
Subject(s) - steric effects , chemistry , supramolecular chemistry , solvation , circular dichroism , hydrogen bond , crystallography , amide , intermolecular force , nuclear magnetic resonance spectroscopy , spectroscopy , vibrational circular dichroism , solvent , stereochemistry , molecule , crystal structure , organic chemistry , physics , quantum mechanics
This work shows that the intuitive assumption of the sterically less hindered amide group being solvated preferentially does not hold for the cases of two 2,6‐pyridinediyl‐dialkylamides. Using vibrational circular dichroism (VCD) spectroscopy, solvation is found to induce significant conformational changes, which are not immediately apparent from 1 H NMR data. More information can be found in the Full Paper by D. P. Demarque and C. Merten on page 17915.