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The Investigation on Resorcinarenes towards either Inhibiting or Promoting Insulin Fibrillation
Author(s) -
Han Xu,
Tian Chuan,
Gandra Ingrid,
Eslava Valeria,
Galindres Diana,
Vargas Edgar,
Leblanc Roger
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704932
Subject(s) - resorcinarene , insulin , fibrillation , chemistry , circular dichroism , drug , molecule , pharmacology , combinatorial chemistry , biochemistry , medicine , atrial fibrillation , organic chemistry
Different tail‐engineered resorcinarenes have been examined for insulin fibrillation by experimental and computational studies. The resorcinarene showed a promising effect on the inhibition of insulin fibrillation, studied using a ThT assay, circular dichroism spectroscopy, and atomic force microscopy. Both the ThT assay and computational results indicate the tail from the resorcinarene has an impact on insulin fibrillation by either inhibition or promotion because of the resident position on insulin. These observations have significant biological implications in the design of drug molecules as well as the development of potential therapeutic strategies.