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Tunable Performance of Manganese Oxide Nanostructures as MRI Contrast Agents
Author(s) -
BañobreLópez Manuel,
GarcíaHevia Lorena,
Cerqueira M. Fatima,
Rivadulla Francisco,
Gallo Juan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704861
Subject(s) - magnetic resonance imaging , manganese , manganese oxide , contrast (vision) , nuclear magnetic resonance , materials science , nanotechnology , chemistry , computer science , medicine , radiology , physics , artificial intelligence , metallurgy
The development of responsive magnetic resonance imaging contrast agents opens the door to a highly sensitive and specific diagnosis of altered physiological conditions. In this field, manganese dioxide (MnO 2 ) is starting to be a leading contributor due to its susceptibility to conditions relevant to human diseased states, such as cancer. So far, the preclinical application of MnO 2 has mainly been in the form of nanosheets, with enhancements of magnetic resonance imaging signals up to 50‐fold upon activation. Herein, we thoroughly investigate, through a simple reaction, a series of Mn x O y samples and correlate their phase composition and structure/morphology to the performance as classic/responsive MRI contrast agents in response to redox changes. Signal enhancements as high as 140‐fold were obtained from MnO 2 nano‐urchins, and their capability as responsive magnetic resonance imaging contrast agents was demonstrated in vitro.