Regio‐ and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N‐Heteroaromatics | Zendy

Wang Haixia | Zendy; Yu Lulu | Zendy; Xie Mingsheng | Zendy; Wu Jiang | Zendy; Qu Guirong | Zendy; Ding Kuiling | Zendy; Guo Haiming | Zendy

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Regio‐ and Enantioselective Allylic Amination of Aliphatic MBH Adducts with N‐Heteroaromatics

Author(s) -

Wang Haixia,

Yu Lulu,

Xie Mingsheng,

Wu Jiang,

Qu Guirong,

Ding Kuiling,

Guo Haiming

Publication year - 2018

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201704772

Subject(s) - amination , enantioselective synthesis , chemistry , allylic rearrangement , benzimidazole , nucleophile , benzotriazole , adduct , stereochemistry , heteroatom , ligand (biochemistry) , selectivity , organic chemistry , catalysis , ring (chemistry) , receptor , biochemistry

Palladium‐catalyzed regio‐ and enantioselective allylic amination of aliphatic Morita‐Baylis–Hillman (MBH) adducts with N‐heteroaromatic nucleophiles (e.g., benzimidazole, 4,5‐diphenylimidazole, benzotriazole, and purines) was achieved by using a spiroketal‐based diphosphine (SKP) ligand, and afforded a range of chiral, branched N ‐allyl products with high selectivity.

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