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Cover Feature: Organocatalytic Asymmetric Synthesis of Spiro‐Tetrahydrothiophene Oxindoles Bearing Four Contiguous Stereocenters by One‐Pot Michael–Henry‐Cascade–Rearrangement Reactions (Chem. Eur. J. 1/2018)
Author(s) -
Wang Shengzheng,
Guo Zhongjie,
Chen Shuqiang,
Jiang Yan,
Zhang Fan,
Liu Xueying,
Chen Weiping,
Sheng Chunquan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704766
Subject(s) - stereocenter , tetrahydrothiophene , nitroaldol reaction , cascade , cascade reaction , chemistry , organocatalysis , stereochemistry , michael reaction , enantioselective synthesis , catalysis , organic chemistry , chromatography
Tetrahydrothiophenes with four contiguous stereocenters were constructed by an unprecedented organocatalytic asymmetric one‐pot Michael–Henry‐cascade−‐rearrangement reaction. The new reaction assembled highly functionalized chiral spiro‐tetrahydrothiophene and spiro‐tetrahydrothiopyran scaffolds in good yields and with excellent stereocontrol. More information can be found in the Communication by S. Wang, C. Sheng et al. on page 62.