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Cover Feature: Difluoroacetic Acid as a New Reagent for Direct C−H Difluoromethylation of Heteroaromatic Compounds (Chem. Eur. J. 72/2017)
Author(s) -
Tung Truong Thanh,
Christensen Søren Brøgger,
Nielsen John
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704732
Subject(s) - chemistry , reagent , radical , decarboxylation , cover (algebra) , oxidative decarboxylation , combinatorial chemistry , nitrogen , catalysis , organic chemistry , mechanical engineering , engineering
Direct C−H difluoromethylation of electron‐deficient positions in nitrogen‐containing heterocycles is attained by difluoromethyl radicals generated in‐situ from difluoroacetic acid under silver‐catalyzed oxidative decarboxylation. Control of the reaction temperature permits either mono‐ or disubstitution. More information can be found in the Communication by J. Nielsen et al. on page 18125.