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Rational Design of Branched Au–Fe 3 O 4 Janus Nanoparticles for Simultaneous Trimodal Imaging and Photothermal Therapy of Cancer Cells
Author(s) -
Chen Xiangjun,
Li Guilan,
Han Qinghe,
Li Xiliang,
Li Lu,
Wang Tingting,
Wang Chungang
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704514
Subject(s) - photothermal therapy , materials science , janus , magnetic resonance imaging , nanoparticle , photoacoustic imaging in biomedicine , nanotechnology , nuclear magnetic resonance , optics , medicine , physics , radiology
We report a facile and simple hydrogen reduction method to fabricate PEGylated branched gold (Au)–iron oxide (Fe 3 O 4 ) Janus nanoparticles (JNPs). Note that the hydrogen induces the formation of Fe 3 O 4 during the synthesis process. Due to the strong absorption in the near‐infrared range, branched Au–Fe 3 O 4 JNPs showed a significant photothermal effect with a 40 % calculated photothermal transduction efficiency under a laser irradiation of 808 nm in vitro. Owing to their excellent optical and magnetic properties, branched Au–Fe 3 O 4 JNPs were demonstrated to be advantageous agents for triple‐modal magnetic resonance imaging (MRI)/photoacoustic imaging (PAI)/computed tomography (CT) in vitro. Therefore, the synthetic approach could be extended to prepare Au–metallic oxide JNPs for specific applications.