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Cover Feature: Direct Access to N‐Unprotected α‐ and/or β‐Tetrasubstituted Amino Acid Esters via Direct Catalytic Mannich‐Type Reactions Using N‐Unprotected Trifluoromethyl Ketimines (Chem. Eur. J. 67/2017)
Author(s) -
Sawa Masanao,
Morisaki Kazuhiro,
Kondo Yuta,
Morimoto Hiroyuki,
Ohshima Takashi
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704439
Subject(s) - stereocenter , chemistry , electrophile , catalysis , vicinal , stereoselectivity , trifluoromethyl , medicinal chemistry , mannich reaction , organocatalysis , organic chemistry , combinatorial chemistry , enantioselective synthesis , alkyl
A new wind blowing : The use of N ‐unprotected trifluoromethyl ketimines as effective electrophiles in direct catalytic Mannich‐type reactions is reported, giving direct access to N ‐unprotected α‐ and/or β‐tetrasubstituted amino acid esters under proton‐transfer conditions. The first stereoselective construction of vicinal tetrasubstituted carbon stereocenters with N ‐unprotected ketimines is also presented. More information can be found in the Full Paper by H. Morimoto and T. Ohshima et al. on page 17022.