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Cover Feature: Designed Synthesis of Au/Fe 3 O 4 @C Janus Nanoparticles for Dual‐Modal Imaging and Actively Targeted Chemo‐Photothermal Synergistic Therapy of Cancer Cells (Chem. Eur. J. 68/2017)
Author(s) -
Zhang Qi,
Zhang Lingyu,
Li Shengnan,
Chen Xiangjun,
Zhang Manjie,
Wang Tingting,
Li Lu,
Wang Chungang
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704227
Subject(s) - photothermal therapy , ethylene glycol , nanoparticle , drug delivery , materials science , folic acid , nanotechnology , peg ratio , doxorubicin , chemistry , chemotherapy , organic chemistry , medicine , surgery , finance , economics
A newly developed approach is presented for the fabrication of new generation of Janus nanoparticles (JNPs)—Au/Fe 3 O 4 @C. These JNPs were functionalized with amino‐poly(ethylene glycol)thiol (NH 2 ‐PEG‐SH) and folic acid (FA) on the exposed Au domains, whereas the mesoporous Fe 3 O 4 @C side served as the drug delivery vehicle of doxorubicin (DOX). The resultant FA‐PEG‐Au/Fe 3 O 4 @C JNPs were employed as a new theranostic agent for CT and MR imaging‐guided actively targeted chemo‐photothermal synergistic therapy of cancer cells. More information can be found in the Full Paper by L. Li, C. Wang et al. on page 17242.