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Direct Aldehyde Csp 2 −H Functionalization through Visible‐Light‐Mediated Photoredox Catalysis
Author(s) -
Vu Minh Duy,
Das Mrinmoy,
Liu XueWei
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704224
Subject(s) - electrophile , photoredox catalysis , chemistry , radical , nucleophile , aldehyde , organic synthesis , surface modification , catalysis , organocatalysis , photochemistry , combinatorial chemistry , reactive intermediate , visible spectrum , organic chemistry , enantioselective synthesis , photocatalysis , materials science , optoelectronics
The development of methods for carbon–carbon bond formation under benign conditions is an ongoing challenge for synthetic chemists. In recent years there has been considerable interest in using selective C−H activation as a direct route for generating reactive intermediates. Herein, the use of visible‐light‐mediated dual photoredox organocatalysis as a mild and effective method for Csp2−H activation of aldehydes is reported, resulting in the generation of acyl radicals. These nucleophilic acyl radical species can undergo either addition to electrophilic alkenes or nickel‐catalyzed cross‐coupling reactions to provide a quick access to broad range of unsymmetrical ketones, which are abundantly found in many organic building blocks.