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Cp*Co III ‐Catalyzed Bis‐isoquinolone Synthesis by C−H Annulation of Arylamide with 1,3‐Diyne
Author(s) -
Sen Malay,
Mandal Rajib,
Das Ashis,
Kalsi Deepti,
Sundararaju Basker
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704155
Subject(s) - annulation , chemoselectivity , catalysis , regioselectivity , chemistry , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
Cp*Co III ‐catalyzed highly regioselective mono‐ and bis‐annulation of arylamides with 1,3‐diynes using N −OMe as an internal oxidant is demonstrated. This atom‐economical transformation does not require any external oxidant and tolerates many functional groups. Various symmetrical and unsymmetrical heterocycles (homo and hetero) are accessed with predictable regio‐ and chemoselectivity.