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Chiral Catenanes and Rotaxanes: Fundamentals and Emerging Applications
Author(s) -
Evans Nicholas H.
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704149
Subject(s) - catenane , enantioselective synthesis , chirality (physics) , scaffold , molecular recognition , nanotechnology , molecule , combinatorial chemistry , chemistry , stereochemistry , catalysis , materials science , computer science , physics , organic chemistry , chiral symmetry breaking , quark , quantum mechanics , database , nambu–jona lasinio model
Molecular chirality provides a key challenge in host–guest recognition and other related chemical applications such as asymmetric catalysis. For a molecule to act as an efficient enantioselective receptor, it requires multi‐point interactions between host and chiral guest, which may be achieved by an appropriate chiral 3D scaffold. As a consequence of their interlocked structure, catenanes and rotaxanes may present such a 3D scaffold, and can be chiral by inclusion of a classical chiral element and/or as a consequence of the mechanical bond. This Minireview presents illustrative examples of chiral [2]catenanes and [2]rotaxanes, and discusses where these molecules have been used in chemical applications such as chiral host–guest recognition and asymmetric catalysis.