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Cover Feature: Investigating Intracellular Localisation and Cytotoxicity Trends for Neutral and Cationic Iridium Tetrazolato Complexes in Live Cells (Chem. Eur. J. 62/2017)
Author(s) -
Caporale Chiara,
Bader Christie A.,
Sorvina Alexandra,
MaGee Karen D. M.,
Skelton Brian W.,
Gillam Todd A.,
Wright Phillip J.,
Raiteri Paolo,
Stagni Stefano,
Morrison Janna L.,
Plush Sally E.,
Brooks Douglas A.,
Massi Massimiliano
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704087
Subject(s) - cationic polymerization , cytotoxicity , iridium , chemistry , intracellular , endoplasmic reticulum , biophysics , biochemistry , biology , polymer chemistry , in vitro , catalysis
Luminescent iridium tetrazolato complexes can be exploited for live cell imaging, and their cellular localization can be modulated by simple methylation of these neutral species to yield the corresponding cationic complexes. The neutral family of complexes displays a tendency to accumulate within the endoplasmic reticulum and, to a variable extent, lipid droplets. The analogous cationic complexes display a tendency to localize primarily in mitochondria. Interestingly, the neutral complexes highlight very low cytotoxicity when compared to their corresponding cationic species. More information can be found in the Full Paper S. E. Plush, D. A. Brooks, M. Massi et al. on page 15666.