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Cover Feature: An Efficient Route to Highly Substituted Indoles via Tetrahydroindol‐4(5 H )‐one Intermediates Produced by Ring‐Opening Cyclization of Spirocyclopropanes with Amines (Chem. Eur. J. 66/2017)
Author(s) -
Nambu Hisanori,
Hirota Wataru,
Fukumoto Masahiro,
Tamura Takafumi,
Yakura Takayuki
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704085
Subject(s) - regioselectivity , chemistry , ring (chemistry) , combinatorial chemistry , cover (algebra) , stereochemistry , organic chemistry , catalysis , mechanical engineering , engineering
An efficient method for the synthesis of highly substituted indoles via tetrahydroindol‐4(5 H )‐one intermediates, prepared by ring‐opening cyclization of spirocyclopropanes with amines, was developed. Syntheses of 4‐, 5‐, 6‐ or 7‐substituted indoles were accomplished by regioselective functionalizations of the intermediates and subsequent oxidation. Furthermore, 4,5,6,7‐tetrasubstituted indoles were synthesized by using these regioselective functionalizations. More information can be found in the Full Paper by H. Nambu, T. Yakura et al. on page 16799.