Auxiliary‐Directed C(sp 3 )−H Arylation by Synergistic Photoredox and Palladium Catalysis | Zendy

Czyz Milena L. | Zendy; Lupton David W. | Zendy; Polyzos Anastasios | Zendy

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Auxiliary‐Directed C(sp 3 )−H Arylation by Synergistic Photoredox and Palladium Catalysis

Author(s) -

Czyz Milena L.,

Lupton David W.,

Polyzos Anastasios

Publication year - 2017

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201704045

Subject(s) - palladium , catalysis , chemistry , photoredox catalysis , combinatorial chemistry , photocatalysis , organic chemistry

Herein we describe the auxiliary‐directed arylation of unactivated C(sp 3 )−H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site‐selective arylation of aliphatic amides with α‐quaternary centres is achieved with high selectivity for β‐methyl C(sp 3 )−H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.

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