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Auxiliary‐Directed C(sp 3 )−H Arylation by Synergistic Photoredox and Palladium Catalysis
Author(s) -
Czyz Milena L.,
Lupton David W.,
Polyzos Anastasios
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704045
Subject(s) - palladium , catalysis , chemistry , photoredox catalysis , combinatorial chemistry , photocatalysis , organic chemistry
Herein we describe the auxiliary‐directed arylation of unactivated C(sp 3 )−H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site‐selective arylation of aliphatic amides with α‐quaternary centres is achieved with high selectivity for β‐methyl C(sp 3 )−H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.