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Amino Acid Coordinated Self‐Assembly
Author(s) -
Zou Qianli,
Yan Xuehai
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201704032
Subject(s) - biomolecule , supramolecular chemistry , amino acid , self assembly , nanotechnology , chemistry , materials science , molecule , biochemistry , organic chemistry
Self‐assembly of highly important biomolecules, such as proteins and peptides, has attracted tremendous interest in supramolecular construction of functional materials. However, as proteins and peptides are often immunogenic and their structures are complex, there is a strong demand to use amino acids as simpler building blocks. Still, mimicking the sophisticated structures and functions of natural materials by self‐assembly of simpler and more basic units of biomolecules, such as amino acids, remains a formidable challenge. Inspired by metal‐ion‐associated crystallization of l ‐cystine in the urinary system, amino acid coordinated self‐assembly is discussed as an original strategy for supramolecular construction of biomimetic materials. The resulting materials possess the features of uniform size, hierarchical architecture, and structural resemblance to biological structures. In addition, the self‐assembly process can readily be adapted to simultaneous integration of various functional modules, providing materials with promising properties for biomimetic and biomedical applications.