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Peroxidase‐Mimicking Nanozyme with Enhanced Activity and High Stability Based on Metal–Support Interactions
Author(s) -
Li Zhihao,
Yang Xiangdong,
Yang Yanbing,
Tan Yaning,
He Yue,
Liu Meng,
Liu Xinwen,
Yuan Quan
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703833
Subject(s) - peroxidase , nanotechnology , nanocomposite , bioanalysis , biomedicine , nanoparticle , biosensor , materials science , cube (algebra) , catalysis , combinatorial chemistry , chemistry , biochemical engineering , computer science , enzyme , organic chemistry , engineering , bioinformatics , mathematics , combinatorics , biology
Peroxidase‐mimicking nanozymes offer unique advantages in terms of high stability and low cost over natural peroxidase for applications in bioanalysis, biomedicine, and the treatment of pollution. However, the design of high‐efficiency peroxidase‐mimicking nanozymes remains a great challenge. In this study, we adopted a structural‐design approach through hybridization of cube‐CeO 2 and Pt nanoparticles to create a new peroxidase‐mimicking nanozyme with high efficiency and excellent stability. Relative to pure cube‐CeO 2 and Pt nanoparticles, the as‐hybridized Pt/cube‐CeO 2 nanocomposites display much improved activities because of the strong metal–support interaction. Meanwhile, the nanocomposites also maintain high catalytic activity after long‐term storage and multiple recycling. Based on their excellent properties, Pt/cube‐CeO 2 nanocomposites were used to construct high‐performance colorimetric biosensors for the sensitive detection of metabolites, including H 2 O 2 and glucose. Our findings highlight opportunities for the development of high‐efficiency peroxidase‐mimicking nanozymes with potential applications such as diagnostics, biomedicine, and the treatment of pollution.