Premium
Synthesis of Functionalized Quinolines through a Reaction of Amides and Alkynes Promoted by Triflic Anhydride/Pyridine
Author(s) -
Li LianHua,
Niu ZhiJie,
Liang YongMin
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703832
Subject(s) - chemoselectivity , electrophile , chemistry , pyridine , combinatorial chemistry , organic chemistry , catalysis
A concise, novel and flexible metal‐free single step to synthesize functionalized quinolines is reported. Triflic anhydride‐mediated (Tf 2 O) activation of amides is discussed in the presence of pyridine to offer strong electrophiles, thereby showcasing excellent productivity, high regio‐ and chemoselectivity, and widely tolerable substrates. This approach provides a straightforward and efficient way to construct azaheterocycle structures.