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Natural Products from Social Amoebae
Author(s) -
Barnett Robert,
Stallforth Pierre
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703694
Subject(s) - multicellular organism , natural (archaeology) , metabolome , biology , diversity (politics) , niche , ecology , microorganism , ecological niche , computational biology , bacteria , metabolomics , bioinformatics , sociology , genetics , habitat , paleontology , gene , anthropology
Natural products are invaluable sources of structural diversity and complexity ideally suited for the development of therapeutic agents. The search for novel bioactive molecules has prompted scientists to explore various ecological niches. Microorganisms have been shown to constitute such an important source. Despite their biosynthetic potential, social amoebae, that is, microorganisms with both a uni‐ and multicellular lifestyle, are underexplored regarding their secreted secondary metabolome. In this review, we present the structural diversity of amoebal natural products and discuss their biological functions as well as their total syntheses.