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Mild Decarboxylative C−H Alkylation: Computational Insights for Solvent‐Robust Ruthenium(II) Domino Manifold
Author(s) -
Kumar N. Y. Phani,
Rogge Torben,
Yetra Santhivardhana Reddy,
Bechtoldt Alexander,
Clot Eric,
Ackermann Lutz
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703680
Subject(s) - ruthenium , decarboxylation , domino , chemistry , catalysis , solvent , alkylation , combinatorial chemistry , organic chemistry
Computational studies on decarboxylative C−H alkenylations provided key insights into the solvent‐robust nature of C−H activation/decarboxylation domino reactions. These properties were exploited for ruthenium(II)‐catalyzed C−H alkylations by a decarboxylative process with ample scope under copper‐free and silver‐free reaction conditions.