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Facile Synthesis of Multiblock Copolymers Containing Sequence‐Controlled Peptides and Well‐Defined Vinyl Polymers by Nitroxide‐Mediated Polymerization
Author(s) -
Nishimura Shinnosuke,
Higashi Nobuyuki,
Koga Tomoyuki
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703655
Subject(s) - copolymer , nitroxide mediated radical polymerization , polymerization , monomer , polymer chemistry , polymer , dispersity , materials science , radical polymerization , styrene , folding (dsp implementation) , intramolecular force , vinyl polymer , chemistry , combinatorial chemistry , organic chemistry , electrical engineering , engineering
Abstract Precisely incorporating a wide range of structural and functional multiblocks along a polymer backbone is a significant challenge in polymer chemistry and offers promising opportunities to design highly ordered materials, including controlled polymer folding. Herein, a facile and versatile strategy for preparing functional multiblock copolymers composed of sequential peptides and well‐defined vinyl polymers with a narrow polydispersity is reported. Cyclic oligopeptides have been developed that contain an alkoxyamine bond in the framework. By using this type of cyclic initiator, peptide‐containing multiblock copolymers are successfully synthesized by nitroxide‐mediated polymerization of styrene. To demonstrate the versatility of this method, radical (co)polymerizations were carried out for different monomers ( p ‐chlorostyrene, 4‐vinylpyridine, and styrene/acrylonitrile) and by three different cyclic peptide initiators with specific amino acid sequences. The resultant multiblock copolymer is foldable through intramolecular interactions between peptide blocks. It is believed that this approach will significantly advance the field of controlled polymer synthesis for complex structures and single‐chain folding.