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Pre‐Assembled Coumarin–Rhodamine Scaffold for Ratiometric Sensing of Nitric Oxide and Hypochlorite
Author(s) -
Ong Jun Xiang,
Pang Victoria Yu Ting,
Tng Li Min,
Ang Wee Han
Publication year - 2018
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703554
Subject(s) - conjugated system , rhodamine , chemistry , acceptor , linker , coumarin , phenylacetylene , photochemistry , combinatorial chemistry , rhodamine b , hypochlorite , fluorescence , organic chemistry , polymer , catalysis , physics , quantum mechanics , photocatalysis , computer science , operating system , condensed matter physics
A new pre‐assembled ratiometric sensing platform was constructed from a coumarin donor and a rhodamine acceptor designed for through‐bond energy transfer (TBET). A phenylacetylene linker was installed to disrupt the planarity of the extended conjugated system but retaining the efficient energy transfer between the donor and acceptor motifs. To demonstrate its versatility as a sensing platform, we conjugated recognition motifs through amide coupling reactions to yield two TBET chemosensors capable of sensing either endogenously produced NO and ClO − . Both probes possessed high selectivity for their analytes, exhibited good stability under physiological conditions, and performed well as bioimaging probes in living cells.