Premium
Metal‐Mediated Base Pairs: From Characterization to Application
Author(s) -
Jash Biswarup,
Müller Jens
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703518
Subject(s) - nucleic acid , nucleobase , base pair , base metal , supramolecular chemistry , metal , combinatorial chemistry , dna , chemistry , nanotechnology , hydrogen bond , bioinorganic chemistry , base (topology) , coordination complex , materials science , stereochemistry , crystallography , biochemistry , molecule , organic chemistry , mathematics , crystal structure , mathematical analysis , welding , metallurgy
The investigation of metal‐mediated base pairs and the development of their applications represent a prominent area of research at the border of bioinorganic chemistry and supramolecular coordination chemistry. In metal‐mediated base pairs, the complementary nucleobases in a nucleic acid duplex are connected by coordinate bonds to an embedded metal ion rather than by hydrogen bonds. Because metal‐mediated base pairs facilitate a site‐specific introduction of metal‐based functionality into nucleic acids, they are ideally suited for use in DNA nanotechnology. This minireview gives an overview of the general requirements that need to be considered when devising a new metal‐mediated base pair, both from a conceptual and from an experimental point of view. In addition, it presents selected recent applications of metal‐modified nucleic acids to indicate the scope of metal‐mediated base pairing.