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Cover Feature: Activatable Near‐Infrared Probe for Fluorescence Imaging of γ‐Glutamyl Transpeptidase in Tumor Cells and In Vivo (Chem. Eur. J. 59/2017)
Author(s) -
Luo Zhiliang,
Feng Liandong,
An Ruibing,
Duan Guanfu,
Yan Runqi,
Shi Hua,
He Jian,
Zhou Zhengyang,
Ji Changge,
Chen HongYuan,
Ye Deju
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703472
Subject(s) - fluorophore , fluorescence , in vivo , linker , chemistry , substrate (aquarium) , biophysics , infrared , microbiology and biotechnology , biochemistry , biology , optics , physics , ecology , computer science , operating system
An activatable near‐infrared probe was developed by linking of a γ‐glutamyl transpeptidase (GGT)‐recognitive substrate, and a near infrared (NIR) fluorophore with a self‐immolative linker. The probe was stable and could generate significant turn‐on fluorescence in response to GGT. The probe was used for the real‐time imaging of GGT activity and screening of GGT inhibitors both in live tumor cells and mice, allowing for the study and diagnosis of GGT‐related diseases. More information can be found in the Full Paper by D. Ye et al. on page 14778.