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Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins
Author(s) -
Salvadó Míriam,
Reina José J.,
Rojo Javier,
Castillón Sergio,
Boutureira Omar
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703432
Subject(s) - glycoconjugate , surface plasmon resonance , topology (electrical circuits) , dispersity , carbohydrate , carbohydrate binding module , chemistry , biophysics , materials science , biochemistry , nanotechnology , biology , organic chemistry , glycoside hydrolase , mathematics , combinatorics , nanoparticle , hydrolysis
Central scaffold topology and carbohydrate density are important features in determining the binding mechanism and potency of synthetic multivalent of poly‐ versus monodisperse carbohydrate systems against a model plant toxin ( Ricinus communis agglutinin (RCA 120 )). Lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations, as determined by surface plasmon resonance and dynamic light scattering.