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Front Picture: α,β‐Unsaturated Amides as Dipolarophiles: Catalytic Asymmetric exo ‐Selective 1,3‐Dipolar Cycloaddition with Nitrones (Chem. Eur. J. 51/2017)
Author(s) -
Zhang Ming,
Kumagai Naoya,
Shibasaki Masakatsu
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703251
Subject(s) - cycloaddition , enantioselective synthesis , chemistry , catalysis , ring (chemistry) , combinatorial chemistry , stereochemistry , organic chemistry
A highly exo ‐selective and enantioselective 1,3‐dipolar cycloaddition of nitrones and α,β‐unsaturated amides was manifested by indium catalyst decorated with chiral bishydroxamic acid ligands. The five‐membered ring system of the product isooxazolines featuring the neighboring nitrogen and oxygen atoms are versatile chiral building blocks in synthetic organic chemistry, and the cover art represents the hypothetical molecular architecture composed of the five‐membered heterocycles. More information can be found in the Communication by M. Zhang, N. Kumagai, and M. Shibasaki on page 12450.