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From Anilines to Quinolines: Iodide‐ and Silver‐Mediated Aerobic Double C−H Oxidative Annulation–Aromatization
Author(s) -
Wu Jiwei,
Liao Zhixiong,
Liu Dong,
Chiang ChienWei,
Li Zheng,
Zhou Zhonghao,
Yi Hong,
Zhang Xu,
Deng Zixin,
Lei Aiwen
Publication year - 2017
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201703218
Subject(s) - aromatization , annulation , quinoline , chemistry , iodide , oxidative phosphorylation , aniline , combinatorial chemistry , organic chemistry , catalysis , biochemistry
Quinoline synthesis from easily accessible raw materials such as anilines is a valuable and meaningful task. Herein, we communicate an iodide‐ and silver‐mediated C−H/C−H oxidative annulation–aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinoline derivatives from inexpensive commodities. Various kinds of anilines, even heterocyclic anilines, were shown to be workable substrates, generating the corresponding multi‐substituted quinolines in good yields.